Astel Malaria ®
Rapid Test for falciparum and vivax Malaria
In eastern and southern
Africa, the greater menace of malaria is caused by 2 species: Plasmodium falciparum which accounts for
around 90 % of all malaria cases and P.
vivax for around 10%. The most lethal malaria is caused by P. falciparum.
Two other malaria species also
infect humans, namely P.malariae, which
causes the so-called “benign malaria”
with fever that recurs at approximately three-day intervals (a quartan fever), and P.ovale, which causes a fever that
recurs every two days “tertian malaria.” Malaria due to these two species is not
nearly as dangerous as that produced by P.
falciparum or P. vivax.
Astel Malaria ® is a rapid highly specific and highly sensitive
test for the detection of infections due to the two dominant malaria species
responsible for nearly all the disease burden in eastern and southern Africa,
namely Plasmodium falciparum and P.vivax.
The test detects parasite species-
specific lactate dehydrogenase (LDH) enzymes using specific monoclonal antibodies.
Since presence of LDH in blood closely correlates with ongoing infections, this
test has high positive and negative predictive values. The test becomes
negative within 4 days following curative treatment, making it also a good
predictor of cure.
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